Our Research Center
Our research program in vascular genomics incorporates novel high-throughput sequencing approaches, new methods to analyze and integrate multi-omic data and genome editing experimental techniques to study heritable mechanisms for atherosclerosis and other vascular disease. Our work benefits from cross-departmental collaborations with geneticists, biomedical engineers, computer scientists, vascular biology scientists and developmental scientists.
The Team
Marios Arvanitis
Associate Professor of Internal Medicine
Division of Cardiovascular Medicine. The Ohio State University
I am a physician scientist with a focus on vascular genetics and genomics. I received my medical degree from the University of Athens, School of Health Sciences in Greece. Then I moved to Brown University for a post-doctoral fellowship in basic sciences and completed my internal medicine residency at Boston University and my cardiology fellowship at Johns Hopkins. I currently devote most of my time to research. I enjoy discussing new projects, papers and ideas with the members of my lab. I also see patients with complex cardiovascular disease and genetic lipid disorders at The Ohio State hospital.
Pablo Toledano Sanz
Research Senior Associate
I was born in Spain where I obtained my Bachelor's degree in Engineering and my Master's degree at the Polytechnic University of Madrid. In 2020, I moved to the United States where I joined the Arvanitis lab in 2021 as a research assistant. Aligned with my research interests in vascular genetics using computational analysis, I am currently working on several projects, identifying transcriptional differences between endothelial cell populations, and developing new approaches to expand our understanding of eQTLs in various endothelial cell types. Outside the lab, I enjoy time with my family and friends, whether at the theater, watching or practicing sports, or enjoying a good dinner.
Alberto Cook Calvete
Post-doctoral Fellow
I received my PhD in cardiovascular and molecular biology, where I developed a strong interest in understanding the mechanisms underlying cardiovascular disease. Currently, I am a Postdoctoral Research Fellow in the Arvanitis Lab at The Ohio State University, where I am developing and refining my expertise in translational cardiovascular research. My project focuses on understanding how epigenetic mechanisms maintain endothelial cell identity and protect against pathological processes such as endothelial-to-mesenchymal transition (EndMT). I also use induced pluripotent stem cell (iPSC)-derived vascular models to investigate how genetic variants influence cellular function and contribute to the early development of atherosclerosis. Outside the lab, I enjoy reading, playing chess, cinema enthusiast, and playing padel.
Maria Delgado Marin
Post-doctoral Fellow
I received my B.Sc. in Biomedical Sciences and my M.Sc. in Therapeutic Targets and Cell Signaling from the University of Alcalá (Madrid, Spain), where I later completed my Ph.D. in Cellular Signaling. My research interests focus on cardiovascular biology and the molecular mechanisms underlying disease development and progression. In 2026, I moved to the United States to join The Ohio State University as a Postdoctoral Scholar in the Arvanitis Lab. Outside the lab, I enjoy reading, discovering new places, and spending time with family and friends.